David M. Loeb; MD, PhD
Chair of the Scientific Advisory Committee
Dr. Loeb is a Professor in the Department of Pediatrics, as well as Development & Molecular Biology at the Albert Einstein College of Medicine. He practices as a pediatric oncologist at the Montefiore Medical Center and serves the Chief of the Department of the Pediatrics Division of Pediatric Hematology /Oncology in Bronx, NY.
Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis, and has used this model to perform preclinical testing of novel agents that can interfere with this process. More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma migration, invasion, and metastasis. Dr. Loeb is also studying the role of an enzyme called RNA helicase DDX3 in Ewing Sarcoma biology, especially how this enzyme affects the repair of damaged DNA. Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3.
When he is not actively working on improving the lives of kids with cancer, he likes to travel, cook – and eat!