Muller Fabbri, MD, PhD
Children's Hospital Los Angeles/University of Hawaii
miRNAs secreted by tumor associated macrophages and resistance in Neuroblastoma
Read About Dr. Fabbri's Findings
Dr. Fabbri’s proposed research project focuses developing an effective but less toxic mechanism for treating Neuroblastoma. It is known that Neuroblastoma can be effectively treated with a type of cell in a person’s body called a Natural Killer Cell. However, Natural Killer Cell therapy is extremely toxic and often must be stopped before a patient can fully receive its benefits. Dr. Fabbri and his lab have found that Natural Killer Cells release little vesicles called exosomes. These exosomes contain many of the important components needed to fight Neuroblastoma. In his research project, Dr. Fabbri would like to further study the mechanism of how these exosomal components kill Neuroblastoma cells and how effectively they work in mice models.