Shahab Asgharzadeh, M.D.

Committee Member

Dr. Shahab Asgharzadeh is an Associate Professor of Pediatrics and Pathology at the University of Southern California. He received his Bachelor’s degree in Biomedical Engineering from Northwestern University in 1992 and medical degree from University of Illinois. He completed pediatric residency and a fellowship in clinical medical ethics at University of Chicago in 2000 and subsequently worked as a research assistant professor in Bioinformatics at Northwestern University. He completed his training in pediatric hematology-oncology at Children’s Hospital Los Angeles prior to joining the faculty of the University of Southern California in 2005.

Dr. Asgharzadeh’s research is directed toward understanding the role of the tumor microenvironment in biology of peripheral and central nervous system tumors, focusing on high-risk neuroblastomas and medulloblastomas. His research using gene expression and next generation sequencing technologies has identified subgroups of these tumors with unique microenvironments. His group’s identification of tumor-associated macrophages in neuroblastomas has helped to better understand the role of the immune system in biology of these tumors. These insights are critical for developing novel immunotherapeutic approaches in the treatment of childhood malignancies.

Dr. Asgharzadeh’s research program is funded by the National Institutes of Health, Department of Defense, American Cancer Society, and several other foundations. He is a member of the NIH sponsored Neuroblastoma Therapeutically Applicable Research to Generate Effective Treatments (Neuroblastoma TARGET) project and an active member of the Children’s Oncology Group and serves on the COG Neuroblastoma Biology Committee.